MRI in Chemotherapy induced Leukoencephalopathy: Report of Two Cases and Radiologist’s Perspective
Published: July 1, 2017 | DOI: https://doi.org/10.7860/JCDR/2017/29164.10248
Geetika Sindhwani, Manali Arora, Vishal Dhirenbhai Thakker, Abhinav Jain
1. Assistant Professor, Department of Radiodiagnosis, Pramukhswami Medical College and Shree Krishna Hospital, Anand, Gujarat, India.
2. Senior Resident, Department of Radiodiagnosis, Pramukhswami Medical College and Shree Krishna Hospital, Anand, Gujarat, India.
3. Senior Resident, Department of Radiodiagnosis, Pramukhswami Medical College and Shree Krishna Hospital, Anand, Gujarat, India.
4. Resident, Department of Urology, Muljibhai Patel Urological Hospital, Nadiad, Gujarat, India.
Correspondence
Dr. Geetika Sindhwani,
Flat-12, Pocket E1, Sector 7, Rohini, New Delhi-110085, India.
E-mail: geetu23130@yahoo.com
Leukoencephalopathy is a progressive white matter disease primarily caused due to myelin damage by a variety of factors. Chemotherapy for oncological treatment is an uncommon but important cause of potentially reversible leukoencephalopathy. In current radiological setting, conventional and diffusion weighted MRI play a significant role in early and accurate detection of this entity. We are hereby presenting MRI evaluation of two cases of methotrexate and 5-fluorouracil induced toxic leukoencephalopathy.
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